The effect of lactulose supplementation on fecal microflora of patients with chronic kidney disease; a randomized clinical trial
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چکیده
INTRODUCTION Lactulose is a prebiotic with bifidogenic and urea reduction effects. It can improve Bifidobacteria and Lactobacilli counts in healthy humans and it may possibly have similar effects in chronic kidney disease (CKD) patients. OBJECTIVES To investigate the effect of lactulose on fecal microflora of patients with CKD. PATIENTS AND METHODS Thirty-two patients with stages 3 and 4 of CKD (43.8% male with mean age of 58.09±12.75 years) were randomly assigned to intervention (n=16) and control (n=16) groups. Patients in intervention group received 30 mm lactulose syrup three times a day for an 8-week period. Control group received placebo 30 mm three times a day. A fecal sample was obtained from all patients at the beginning and at the end of the study and Bifidobacteria and Lactobacilli was counted. RESULTS Creatinine (Cr) significantly decreased in intervention group (3.90±1.43 to 3.60±1.44, P=0.003) and increased in control group (3.87±2.08 to 4.11±1.99, P=0.03). Although Bifidobacterial and Lactobacilli counts were similar before intervention, they were significantly higher at the end of the study in lactulose group (P=0.01 and P=0.04, respectively). Lactulose led to significant increase in fecal Bifidobacterial counts (3.61±0.54 to 4.90±0.96, P<0.001) and Lactobacilli counts (2.79±1.00 to 3.87±1.13, P<0.001), while the change in placebo group was not significant. CONCLUSION Lactulose administration will increase Bifidobacteria and Lactobacillus counts in patients with CKD.
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Lactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure.
Abstract Introduction. Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease. Patients with chronic kidney disease (CKD) face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function. Lactulose is a hyper osmotic agent and as a prebiotic could reduce serum urea and p...
متن کاملLactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure
Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stagedisease. Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overloadin CKD patients is associated with rapid decline in kidney function. Lactulose is a hyper osmotic agent andas a prebiotic plays an important role in regulating serum urea and potassiu...
متن کاملLactulose efficacy in reduction of nitrogen products,blood potassium and fluid overload in patients with end-stage renal failure ..
Introduction.Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease.Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function.Lactulose is a hyper osmotic agent and as a prebioticplays an important role in regulating serum urea...
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